AustralieFrV1, Main, Exploration, bibRecord, 003797

Inherited variation at MC1R and ASIP and association with melanoma-specific survival

Identifieur interne : 003797 ( Main/Exploration ); précédent : 003796; suivant : 003798

Inherited variation at MC1R and ASIP and association with melanoma-specific survival

Auteurs : Nicholas J. Taylor [États-Unis] ; Anne S. Reiner [États-Unis] ; Colin B. Begg [États-Unis] ; Anne E. Cust [Australie] ; Klaus J. Busam [États-Unis] ; Hoda Anton-Culver [États-Unis] ; Terence Dwyer [France] ; Lynn From [Canada] ; Richard P. Gallagher [Canada] ; Stephen B. Gruber [États-Unis] ; Stefano Rosso [Italie] ; Kirsten A. White [États-Unis] ; Roberto Zanetti [Italie] ; Irene Orlow [États-Unis] ; Nancy E. Thomas [États-Unis] ; Timothy R. Rebbeck [États-Unis] ; Marianne Berwick [États-Unis] ; Peter A. Kanetsky [États-Unis]

Source :

International journal of cancer. Journal international du cancer [ 0020-7136 ] ; 2014.

RBID : PMC:4361274

Abstract

MC1R is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into the GEM study. MC1R genotype data was available for 2,200 participants with a first incident primary melanoma diagnosis. We estimated the association of MC1R genotypes with melanoma-specific survival (i.e. death due to melanoma) and overall survival using Cox proportional hazards modeling, adjusting for established prognostic factors for melanoma. We also conducted stratified analyses by Breslow thickness, tumor site, phenotypic index and age. Additionally, we evaluated haplotypes involving polymorphisms near the ASIP locus for their impacts on survival. Melanoma-specific survival was inversely associated with carriage of MC1R variants in the absence of consensus alleles compared to carriage of at least one consensus allele (HR=0.60; 95%CI: 0.40, 0.90). MC1R results for overall survival were consistent with no association. We did not observe any statistical evidence of heterogeneity of effect estimates in stratified analyses. We observed increased hazard of melanoma-specific death among carriers of the risk haplotype TG near the ASIP locus (HR=1.37; 95%CI: 0.91, 2.04) when compared to carriers of the most common GG haplotype. Similar results were noted for overall survival. Upon examining the ASIP TG/TG diplotype, we observed considerably increased hazard of melanoma-specific death (HR=5.11; 95%CI: 1.88, 13.88) compared to carriers of the most common GG/GG diplotype. Our data suggest improved melanoma-specific survival among carriers of two inherited MC1R variants.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361274

DOI: 10.1002/ijc.29317
PubMed: 25382380
PubMed Central: 4361274

Affiliations:

Le document en format XML

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 and <italic>ASIP</italic>
 and association with melanoma-specific survival</title>
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<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
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<author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
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<author><name sortKey="Orlow, Irene" sort="Orlow, Irene" uniqKey="Orlow I" first="Irene" last="Orlow">Irene Orlow</name>
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<author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
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<wicri:regionArea>Departments of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, MSC 10-5550 University of New Mexico, Albuquerque, NM</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inherited variation at <italic>MC1R</italic>
 and <italic>ASIP</italic>
 and association with melanoma-specific survival</title>
<author><name sortKey="Taylor, Nicholas J" sort="Taylor, Nicholas J" uniqKey="Taylor N" first="Nicholas J." last="Taylor">Nicholas J. Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reiner, Anne S" sort="Reiner, Anne S" uniqKey="Reiner A" first="Anne S." last="Reiner">Anne S. Reiner</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Begg, Colin B" sort="Begg, Colin B" uniqKey="Begg C" first="Colin B." last="Begg">Colin B. Begg</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney, Sydney, NSW</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Busam, Klaus J" sort="Busam, Klaus J" uniqKey="Busam K" first="Klaus J" last="Busam">Klaus J. Busam</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY</wicri:regionArea>
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<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California, Irvine, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Cancer Research, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="From, Lynn" sort="From, Lynn" uniqKey="From L" first="Lynn" last="From">Lynn From</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Women’s College Hospital, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
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<author><name sortKey="Gallagher, Richard P" sort="Gallagher, Richard P" uniqKey="Gallagher R" first="Richard P" last="Gallagher">Richard P. Gallagher</name>
<affiliation wicri:level="1"><nlm:aff id="A8">British Columbia Cancer Agency, Vancouver, BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>British Columbia Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
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<author><name sortKey="Rosso, Stefano" sort="Rosso, Stefano" uniqKey="Rosso S" first="Stefano" last="Rosso">Stefano Rosso</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Piedmont Tumor Registry, Turin</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
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</placeName>
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<author><name sortKey="White, Kirsten A" sort="White, Kirsten A" uniqKey="White K" first="Kirsten A." last="White">Kirsten A. White</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Departments of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, MSC 10-5550 University of New Mexico, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, MSC 10-5550 University of New Mexico, Albuquerque, NM</wicri:regionArea>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zanetti, Roberto" sort="Zanetti, Roberto" uniqKey="Zanetti R" first="Roberto" last="Zanetti">Roberto Zanetti</name>
<affiliation wicri:level="3"><nlm:aff id="A10">Piedmont Tumor Registry, Turin, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Piedmont Tumor Registry, Turin</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orlow, Irene" sort="Orlow, Irene" uniqKey="Orlow I" first="Irene" last="Orlow">Irene Orlow</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Nancy E" sort="Thomas, Nancy E" uniqKey="Thomas N" first="Nancy E." last="Thomas">Nancy E. Thomas</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A13">Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berwick, Marianne" sort="Berwick, Marianne" uniqKey="Berwick M" first="Marianne" last="Berwick">Marianne Berwick</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Departments of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, MSC 10-5550 University of New Mexico, Albuquerque, NM, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, MSC 10-5550 University of New Mexico, Albuquerque, NM</wicri:regionArea>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of cancer. Journal international du cancer</title>
<idno type="ISSN">0020-7136</idno>
<idno type="eISSN">1097-0215</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>MC1R</italic>
 is a marker of melanoma risk in populations of European ancestry. However, <italic>MC1R</italic>
 effects on survival are much less studied. We investigated associations between variation at <italic>MC1R</italic>
 and survival in an international, population-based series of single primary melanoma patients enrolled into the GEM study. <italic>MC1R</italic>
 genotype data was available for 2,200 participants with a first incident primary melanoma diagnosis. We estimated the association of <italic>MC1R</italic>
 genotypes with melanoma-specific survival (<italic>i.e.</italic>
 death due to melanoma) and overall survival using Cox proportional hazards modeling, adjusting for established prognostic factors for melanoma. We also conducted stratified analyses by Breslow thickness, tumor site, phenotypic index and age. Additionally, we evaluated haplotypes involving polymorphisms near the <italic>ASIP</italic>
 locus for their impacts on survival. Melanoma-specific survival was inversely associated with carriage of <italic>MC1R</italic>
 variants in the absence of consensus alleles compared to carriage of at least one consensus allele (HR=0.60; 95%CI: 0.40, 0.90). <italic>MC1R</italic>
 results for overall survival were consistent with no association. We did not observe any statistical evidence of heterogeneity of effect estimates in stratified analyses. We observed increased hazard of melanoma-specific death among carriers of the risk haplotype TG near the <italic>ASIP</italic>
 locus (HR=1.37; 95%CI: 0.91, 2.04) when compared to carriers of the most common GG haplotype. Similar results were noted for overall survival. Upon examining the <italic>ASIP</italic>
 TG/TG diplotype, we observed considerably increased hazard of melanoma-specific death (HR=5.11; 95%CI: 1.88, 13.88) compared to carriers of the most common GG/GG diplotype. Our data suggest improved melanoma-specific survival among carriers of two inherited <italic>MC1R</italic>
 variants.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Floride</li>
<li>Nouveau-Mexique</li>
<li>Nouvelle-Galles du Sud</li>
<li>Pennsylvanie</li>
<li>Piémont</li>
<li>Rhône-Alpes</li>
<li>État de New York</li>
</region>
<settlement><li>Los Angeles</li>
<li>Lyon</li>
<li>Sydney</li>
<li>Turin</li>
</settlement>
<orgName><li>Université de Californie du Sud</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Taylor, Nicholas J" sort="Taylor, Nicholas J" uniqKey="Taylor N" first="Nicholas J." last="Taylor">Nicholas J. Taylor</name>
</region>
<name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<name sortKey="Begg, Colin B" sort="Begg, Colin B" uniqKey="Begg C" first="Colin B." last="Begg">Colin B. Begg</name>
<name sortKey="Berwick, Marianne" sort="Berwick, Marianne" uniqKey="Berwick M" first="Marianne" last="Berwick">Marianne Berwick</name>
<name sortKey="Busam, Klaus J" sort="Busam, Klaus J" uniqKey="Busam K" first="Klaus J" last="Busam">Klaus J. Busam</name>
<name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
<name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
<name sortKey="Orlow, Irene" sort="Orlow, Irene" uniqKey="Orlow I" first="Irene" last="Orlow">Irene Orlow</name>
<name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<name sortKey="Reiner, Anne S" sort="Reiner, Anne S" uniqKey="Reiner A" first="Anne S." last="Reiner">Anne S. Reiner</name>
<name sortKey="Thomas, Nancy E" sort="Thomas, Nancy E" uniqKey="Thomas N" first="Nancy E." last="Thomas">Nancy E. Thomas</name>
<name sortKey="White, Kirsten A" sort="White, Kirsten A" uniqKey="White K" first="Kirsten A." last="White">Kirsten A. White</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name>
</region>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="From, Lynn" sort="From, Lynn" uniqKey="From L" first="Lynn" last="From">Lynn From</name>
</noRegion>
<name sortKey="Gallagher, Richard P" sort="Gallagher, Richard P" uniqKey="Gallagher R" first="Richard P" last="Gallagher">Richard P. Gallagher</name>
</country>
<country name="Italie"><region name="Piémont"><name sortKey="Rosso, Stefano" sort="Rosso, Stefano" uniqKey="Rosso S" first="Stefano" last="Rosso">Stefano Rosso</name>
</region>
<name sortKey="Zanetti, Roberto" sort="Zanetti, Roberto" uniqKey="Zanetti R" first="Roberto" last="Zanetti">Roberto Zanetti</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Inherited variation at MC1R and ASIP and association with melanoma-specific survival

Inherited variation at MC1R and ASIP and association with melanoma-specific survival

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